Ambra Giglia-Mari – PGNM

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Pierre-Olivier Mari

About

I have always been curious about how life works, a curiosity that has guided both my scientific path and my way of living. I am naturally energetic and full of ideas, and over time I have learned how to channel this energy into meaningful projects.

As a group leader, I feel a strong sense of responsibility toward my team. My priority is to ensure that everyone feels well, supported, and valued, both as scientists and as individuals.

Beyond research, I love helping people — whether they are close friends or new acquaintances. Sometimes this means bringing joy and comfort through my long-time passion for raising kittens, which I have pursued for over 15 years, and other times by offering advice, often rooted in my scientific knowledge.

What inspires me the most is Nature: I have always been fascinated by life in all its forms. I am passionate about the sea and sports connected to it, and I also dedicate much time to writing — not only scientific articles and grants, but also personal reflections. Meeting people and sharing ideas is another source of joy and inspiration for me.

For me, life and science are inseparable journeys of curiosity, care, and connection, guiding everything I do.

Events

SMNuHoMICS at the JPND Symposium

Ambra Giglia-Mari, Candice Benedetti

It was a pleasure to present the progress of the SMNuHoMICS project at the NEURON & JPND – EU Joint […]

Team Mari at the SMA Europe Congress

Phoebe Rassinoux, Ambra Giglia-Mari, Lise-Marie Donnio

Three members of the team were delighted to attend the SMA Europe Congress at Budapest, where patients, families, industry representatives, […]

The Mari team wishes you a Merry Christmas and a Happy New Year 2026

Lise-Marie Donnio, Pierre-Olivier Mari, Ambra Giglia-Mari +8 more

With enthusiasm and determination, we look forward to the year ahead, ready to embrace new challenges, advance our work, and […]

Visit to Ottawa

Lise-Marie Donnio, Ambra Giglia-Mari, Pierre-Olivier Mari

We are delighted to have met once again our collaborators Olivier Binda and Jocelyn Côté in real life and discussed […]

Projects

How SMN Protein Moves and Maintains Nucleolar Health

Principal investigator Ambra Giglia-Mari

Team: Nucleolar Dynamic during DNA Repair in action (Nu-DyRection)

How Cajal Bodies and the Nucleolus Respond to DNA Damage

Principal investigator Ambra Giglia-Mari

Team: Nucleolar Dynamic during DNA Repair in action (Nu-DyRection)

Protecting SMN-Deficient Cells from Oxidative Stress

Principal investigator Ambra Giglia-Mari

Team: Nucleolar Dynamic during DNA Repair in action (Nu-DyRection)

Studying SMN Function in Post-Mitotic Cells

Principal investigator Ambra Giglia-Mari

Team: Nucleolar Dynamic during DNA Repair in action (Nu-DyRection)

Publications

Donnio LM, Giglia-Mari G, Keep calm and reboot – how cells restart transcription after DNA damage and DNA repair, FEBS Lett 2025 Jan; 599(2): 275-294.

Belotti E, Lacoste N, Iftikhar A, Simonet T, Papin C, Osseni A, Streichenberger N, Mari PO, Girard E..., H2A.Z is involved in premature aging and DSB repair initiation in muscle fibers., Nucleic Acids Res 2024 Apr; 52(6): 3031-3049.

Sutcu HH, Rassinoux P, Donnio LM, Neuillet D, Vianna F, Gabillot O, Mari PO, Baldeyron C, Giglia-Mar..., Decline of DNA damage response along with myogenic differentiation., Life Sci Alliance 2024 Feb; 7(2): .

Sandoz J, Cigrang M, Zachayus A, Catez P, Donnio LM, Elly C, Nieminuszczy J, Berico P, Braun C, Alek..., Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress, Nat Commun 2023 Jan; 14(1): 341.

Musawi S, Donnio LM, Zhao Z, Magnani C, Rassinoux P, Binda O, Huang J, Jacquier A, Coudert L, Lomont..., Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments, Nat Commun 2023 Nov; 14(1): 7384.

Elena Cerutti, Laurianne Daniel, Lise-Marie Donnio, Damien Neuillet, Charlene Magnani, Pierre-Olivie..., β-Actin and Nuclear Myosin I are responsible for nucleolar reorganization during DNA Repair, .

Shaqraa Musawi, Lise-Marie Donnio, Charlène Magnani, Olivier Binda, Jocelyn Côté, Patrick Lomonte..., Nucleolar Reorganization After Cellular Stress is Orchestrated by SMN Shuttling Between Nuclear Compartments, .

Donnio LM, Cerutti E, Magnani C, Neuillet D, Mari PO, Giglia-Mari G, XAB2 dynamics during DNA damage-dependent transcription inhibition, Elife 2022 Jul; 11(): .

Taupelet F, Donnio LM, Magnani C, Mari PO, Giglia-Mari G, A stable XPG protein is required for proper ribosome biogenesis: Insights on the phenotype of combinate Xeroderma Pigmentosum/Cockayne Syndrome patients, PLoS One 2022 ; 17(7): e0271246.

Donnio LM, Miquel C, Vermeulen W, Giglia-Mari G, Mari PO, Cell-type specific concentration regulation of the basal transcription factor TFIIH in XPBy/y mice model, Cancer Cell Int 2019 ; 19(): 237.

Alain Sarasin, Giuseppina Giglia-Mari, p53 gene mutations in human skin cancers., Experimental Dermatology.

Donnio LM, Lagarou A, Sueur G, Mari PO, Giglia-Mari G, CSB-Dependent Cyclin-Dependent Kinase 9 Degradation and RNA Polymerase II Phosphorylation during Transcription-Coupled Repair., Mol Cell Biol 2019 Mar; 39(6): .

Daniel L, Cerutti E, Donnio LM, Nonnekens J, Carrat C, Zahova S, Mari PO, Giglia-Mari G, Mechanistic insights in transcription-coupled nucleotide excision repair of ribosomal DNA., Proc Natl Acad Sci U S A 2018 Jul; 115(29): E6770-E6779.

Mourgues S, Gautier V, Lagarou A, Bordier C, Mourcet A, Slingerland J, Kaddoum L, Coin F, Vermeulen ..., ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair., Proc Natl Acad Sci U S A 2013 Oct; 110(44): 17927-32.

Julie Nonnekens, Jorge Perez-Fernandez, Arjan F Theil, Olivier Gadal, Chrystelle Bonnart, Giuseppina..., Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing, Human Molecular Genetics.

Marion Maisonobe, Giuseppina Giglia-Mari, Denis Eckert, DNA Repair: A changing geography? (1964–2008), DNA Repair.

Lara Kaddoum, Nicolas Panayotis, Honoré Mazarguil, Giuseppina Giglia-Mari, Jean Christophe Roux, Et..., Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain, F1000Research.

Godon C, Mourgues S, Nonnekens J, Mourcet A, Coin F, Vermeulen W, Mari PO, Giglia-Mari G, Generation of DNA single-strand displacement by compromised nucleotide excision repair., EMBO J 2012 Aug; 31(17): 3550-63.

Frédéric Coin, Bernardo Reina-San-Martin, Giuseppina Giglia-Mari, Mark Berneburg, DNA in 3R: Repair, Replication, and Recombination, Biochemistry and molecular biology international.

G. Giglia-Mari, A. Zotter, W. Vermeulen, DNA Damage Response, Cold Spring Harbor Perspectives in Biology.

Overmeer RM, Gourdin AM, Giglia-Mari A, Kool H, Houtsmuller AB, Siegal G, Fousteri MI, Mullenders LH..., Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment., Mol Cell Biol 2010 Oct; 30(20): 4828-39.

Giglia-Mari G, Theil AF, Mari PO, Mourgues S, Nonnekens J, Andrieux LO, de Wit J, Miquel C, Wijgers ..., Differentiation driven changes in the dynamic organization of Basal transcription initiation., PLoS Biol 2009 Oct; 7(10): e1000220.

Simone Sabbioneda, Audrey Gourdin, Catherine Green, Angelika Zotter, Giuseppina Giglia-Mari, Adriaan..., Effect of Proliferating Cell Nuclear Antigen Ubiquitination and Chromatin Structure on the Dynamic Properties of the Y-family DNA Polymerases, Molecular Biology of the Cell.

Giuseppina Giglia-Mari, Alain Sarasin, TP53 mutations in human skin cancers, Human Mutation.

Alain Spatz, Giuseppina Giglia-Mari, Simone Benhamou, Alain Sarasin, Association between DNA repair-deficiency and high level of p53 mutations in melanoma of Xeroderma pigmentosum, Cancer Research.