Projects
Research projects led by PGNM teams and collaborators.
Explore research projects connected to PGNM teams, facilities and partners, from fundamental mechanisms to translational programmes.
A single nucleus approach solving the role of MuSCs in myofiber rejuvenation
Principal investigator
Rémi Mounier
Principal investigator
Anita Kneppers
Team: Striated Muscle Metabolic Cross-Talk in Health and Disease
Autophagy/mitophagy regulation in striated skeletal muscle and in the context of Myotonic Dystrophy type 1
Principal investigator
Flavie Strappazzon
Team: Autophagy in pathophysiology
Better characterize the beneficial role of a variant of the autophagic receptor NDP52 in the context of Alzheimer’s disease
Principal investigator
Flavie Strappazzon
Team: Autophagy in pathophysiology
Deciphering the signaling pathways regulated by the primary cilium in muscle stem cells
Principal investigator
Caroline Brun
Team: Architecture du noyau et du cytosquelette musculaire
Developing pre-clinical therapeutic approaches
Principal investigator
Hélène Puccio
Team: Fundamental and pathophysiological mechanisms implicated in ataxia
Disease Mutations Disrupting Excitability and EC Coupling in Skeletal Muscle
Principal investigator
Vincent Jacquemond
Team: Excitability and calcium signaling in normal and diseased skeletal muscle
Dynamics of autophagy within neurons
Principal investigator
Pascale Bomont
Team: Mechanisms and therapies for neuromuscular diseases
Epigenetic regulation of muscle stem cell fate
Principal investigator
Isabella Scionti
Team: Nerve-muscle interactions
Evolution of the microtubule proteome and its involvement in the formation and maintenance of nuclear domains (MNDs) during skeletal muscle development
Principal investigator
Vincent Gache
Team: Architecture du noyau et du cytosquelette musculaire
HDAC6
Principal investigator
Alexis Osseni
Team: Nerve-muscle interactions
Histone variants
Principal investigator
Edwige Belotti
Team: Nerve-muscle interactions
How Cajal Bodies and the Nucleolus Respond to DNA Damage
Principal investigator
Ambra Giglia-Mari
Team: Nucleolar Dynamic during DNA Repair in action (Nu-DyRection)
How SMN Protein Moves and Maintains Nucleolar Health
Principal investigator
Ambra Giglia-Mari
Team: Nucleolar Dynamic during DNA Repair in action (Nu-DyRection)
Identification and validation of biomarkers for FA and ARCA2
Principal investigator
Hélène Puccio
Team: Fundamental and pathophysiological mechanisms implicated in ataxia
Investigate the importance of mitophagy in the context of neurodevelopment
Principal investigator
Flavie Strappazzon
Team: Autophagy in pathophysiology
Mechanisms of membrane trafficking in differentiated cells
Principal investigator
Gaelle Boncompain
Team: Architecture du noyau et du cytosquelette musculaire
Metabolic regulations of adult muscle stem cell fate
Principal investigator
Rémi Mounier
Team: Striated Muscle Metabolic Cross-Talk in Health and Disease
Modulation of skeletal muscle integrity in healthy and pathological contexts
Principal investigator
Carole Kretz-Remy
Team: Architecture du noyau et du cytosquelette musculaire
Motoneuron and NMJ genetic diseases
Principal investigator
Arnaud Jacquier
Team: Nerve-muscle interactions
mTOR signaling
Principal investigator
Yann-gaël Gangloff
Team: Nerve-muscle interactions