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About

My passion for research began during several outstanding internships I completed as an undergraduate student in Grenoble. After earning my Master’s degree at ENS Lyon, which included two semesters of research internships, I pursued a PhD at the IGBMC near Strasbourg. There, I showed that different mutations in the MED12 subunit of the Mediator complex cause specific defects in gene expression regulation.

I joined Ambra’s team in November 2015 as a post-doctoral researcher. I identified TFIIH as a marker of transcriptional activity and uncovered the role of XAB2 in DNA damage recognition during transcription-coupled repair. I’m now exploring how the SMN protein contributes to nucleolar reorganization after genotoxic stress.

To make my colleagues’ lives easier, I create ImageJ macros to quantify specific fluorescence signals automatically.
Outside of research, I love playing the trumpet. I used to be in an orchestra, but these days I only play in a marching band with my partner and kids. I also enjoy hands-on activities like baking pastries, decorating windows, doing cross-stitch, or tackling complex puzzles.

Publications

2024
Donnio LM, Giglia-Mari G, Keep calm and reboot – how cells restart transcription after DNA damage and DNA repair, FEBS Lett 2025 Jan; 599(2): 275-294.
2024
Sutcu HH, Rassinoux P, Donnio LM, Neuillet D, Vianna F, Gabillot O, Mari PO, Baldeyron C, Giglia-Mar..., Decline of DNA damage response along with myogenic differentiation., Life Sci Alliance 2024 Feb; 7(2): .
2023
Sandoz J, Cigrang M, Zachayus A, Catez P, Donnio LM, Elly C, Nieminuszczy J, Berico P, Braun C, Alek..., Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress, Nat Commun 2023 Jan; 14(1): 341.
2023
Musawi S, Donnio LM, Zhao Z, Magnani C, Rassinoux P, Binda O, Huang J, Jacquier A, Coudert L, Lomont..., Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments, Nat Commun 2023 Nov; 14(1): 7384.
2022
Donnio LM, Cerutti E, Magnani C, Neuillet D, Mari PO, Giglia-Mari G, XAB2 dynamics during DNA damage-dependent transcription inhibition, Elife 2022 Jul; 11(): .
2022
Taupelet F, Donnio LM, Magnani C, Mari PO, Giglia-Mari G, A stable XPG protein is required for proper ribosome biogenesis: Insights on the phenotype of combinate Xeroderma Pigmentosum/Cockayne Syndrome patients, PLoS One 2022 ; 17(7): e0271246.
2019
Donnio LM, Miquel C, Vermeulen W, Giglia-Mari G, Mari PO, Cell-type specific concentration regulation of the basal transcription factor TFIIH in XPBy/y mice model, Cancer Cell Int 2019 ; 19(): 237.
2018
Daniel L, Cerutti E, Donnio LM, Nonnekens J, Carrat C, Zahova S, Mari PO, Giglia-Mari G, Mechanistic insights in transcription-coupled nucleotide excision repair of ribosomal DNA., Proc Natl Acad Sci U S A 2018 Jul; 115(29): E6770-E6779.
2017
Epanchintsev A, Costanzo F, Rauschendorf MA, Caputo M, Ye T, Donnio LM, Proietti-de-Santis L, Coin F..., Cockayne’s Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation., Mol Cell 2017 Dec; 68(6): 1054-1066.e6.
2017
Donnio LM, Bidon B, Hashimoto S, May M, Epanchintsev A, Ryan C, Allen W, Hackett A, Gecz J, Skinner ..., MED12-related XLID disorders are dose-dependent of immediate early genes (IEGs) expression., Hum Mol Genet 2017 Jun; 26(11): 2062-2075.