Novel cylic AMP signalosome in cardiac remodeling and heart failure

Description

Abstract The compartmentation of signaling processes is accomplished by the assembly of protein complexes called signalosomes. These signaling platforms colocalize enzymes, substrates, and anchoring proteins into specific subcellular compartments. Exchange protein directly activated by cAMP 1 (EPAC1) is an effector of the second messenger, 3′,5′-cyclic adenosine monophosphate (cAMP) that is associated with multiple roles in several pathologies including cardiac diseases. Both EPAC1 intracellular localization and molecular partners are key players in the regulation of cell fate, which may have important therapeutic potential. Here, we summarize the recent findings on EPAC1 structure, regulation, and pharmacology. We discuss the importance of EPAC1 subcellular distribution in its biological action, paying special attention to its mechanism of action leading to cardiomyocyte death in stress conditions.

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