About
The main focus of the team is to understand the importance of autophagy and the selective autophagy of mitochondria (the so called mitophagy) processes in physiological conditions such as aging, neurodevelopment. Also, we aim to better understand how these processes are deregulated in pathologies such as neurodegenerative diseases, muscular disease and to develop tools to manipulate them. We believe that our goals are of the utmost importance in the biology of neurogenerative diseases, but also in the context of muscular diseases since autophagy is deregulated in many of these disorders. To this end, we are combining techniques such as biochemistry (western-blotting, immunoprecipitation, kinase assay etc…), confocal microscopy analysis, in vivo manipulation of autophagy in brain of mice (injection of AAV encoding autophagic proteins or fluorescent reporters of mitophagy; nanoparticle manipulation etc.).
Projects
Better understand the autophagy/mitophagy regulation in striated skeletal muscle and in the context of Myotonic Dystrophy type 1