Armelle Corpet – PGNM

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About

Associate Professor in Lyon 1 University, I teach Genetics, Epigenetics and molecular biology with passion.
My research focuses on the role of various histone chaperones, chromatin modifiers and specific nuclear bodies (PML NBs) in the regulation of chromatin dynamics in various physiopathological processes.

Events

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Nuclear dynamics of cGAS upon DNA-damage induced senescence

Florent Bressac

men and women sitting on chairs inside room

Implication of the SETDB1-HUSH-MORC2 axis in the control of herpes simplex virus 1 latency

The human body is colonized by numerous commensal microorganisms forming the human microbiota. The human microbiota is now recognized as […]

men and women sitting on chairs inside room

Role of PML nuclear bodies and of the histone chaperone complex HIRA in the regulation of chromatin dynamics

Constance Kleijwegt

Within the nucleus of eucaryotic cells, DNA is wrapped around histone proteins in order to form a structure called chromatin. […]

News

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Girls are perfect for science

Two INMG researchers are featured in the book Girls are perfect for science. Through this book, discover 48 portraits of […]

Publications

Bouchereau W, Chenane L, Weiss-Gayet M, Lessard L, Cardona Y, Mounier R, Gallay L, Allenbach Y, Benv..., Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway., NAR Mol Med 2026 Apr; 3(2): ugag022.

Florent Bressac, Tristan Bargain, Constance Kleijwegt, Wilhelm Bouchereau, Lucas Bonnefoy, Karine Mo..., A p97-PML NBs axis is essential for chromatin-bound cGAS untethering and degradation upon senescence-prone DNA damage, .

Escure T, Corpet A, Juillard F, Lomonte P, [Lethargy in progress! The HUSH complex controls HSV-1 latency]., Med Sci (Paris) 2025 Oct; 41(10): 737-740.

Roubille S, Escure T, Juillard F, Corpet A, Néplaz R, Binda O, Seurre C, Gonin M, Bloor S, Cohen C,..., The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomes., Proc Natl Acad Sci U S A 2024 Dec; 121(49): e2412258121.

Binda O, Kimenyi Ishimwe AB, Galloy M, Jacquet K, Corpet A, Fradet-Turcotte A, Côté J, Lomonte P, The TUDOR domain of SMN is an H3K79me1 histone mark reader., Life Sci Alliance 2023 Jun; 6(6): .

Kleijwegt C, Bressac F, Seurre C, Bouchereau W, Cohen C, Texier P, Simonet T, Schaeffer L, Lomonte P..., Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus., Elife 2023 May; 12(): .

Binda O, Juillard F, Ducassou JN, Kleijwegt C, Paris G, Didillon A, Baklouti F, Corpet A, Couté Y, ..., SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members., Life Sci Alliance 2023 Jan; 6(1): .

Gallay L, Fermon C, Lessard L, Weiss-Gayet M, Viel S, Streichenberger N, Corpet A, Mounier R, Gitiau..., Involvement of Type I Interferon Signaling in Muscle Stem Cell Proliferation During Dermatomyositis., Neurology 2022 May; 98(21): e2108-e2119.

Corpet A, Kleijwegt C, Roubille S, Juillard F, Jacquet K, Texier P, Lomonte P, PML nuclear bodies and chromatin dynamics: catch me if you can!, Nucleic Acids Res 2020 Dec; 48(21): 11890-11912.

Cohen C, Corpet A, Maroui MA, Juillard F, Lomonte P, Latent/Quiescent Herpes Simplex Virus 1 Genome Detection by Fluorescence In Situ Hybridization (FISH)., Methods Mol Biol 2020 ; 2060(): 185-197.

Adam S, Dabin J, Chevallier O, Leroy O, Baldeyron C, Corpet A, Lomonte P, Renaud O, Almouzni G, Polo..., Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage., Mol Cell 2016 Oct; 64(1): 65-78.

Maroui MA, Callé A, Cohen C, Streichenberger N, Texier P, Takissian J, Rousseau A, Poccardi N, Wels..., Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment., PLoS Pathog 2016 Sep; 12(9): e1005834.

Funding