Developmental origins of late-onset neurological diseases

Description

Abstract
Alzheimer disease, Parkinson disease, and Huntington disease (HD), present their full-blown forms typically after mid-adulthood. Most research on these conditions has sought to unravel the causes of the motor and cognitive deterioration and pathologies such as the clumping of proteins and neuronal death. Sandrine Humbert’s team combines cellular approaches with mouse models to understand the physiological functions of huntingtin and the mechanisms underlying Huntington disease pathogenesis.