Jean-Luc Thomas – PGNM

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Charlène Magnani

About

Born in Paris, I spent my childhood near Tours and my summers in the deep countryside of Berry, on the edge of a forest. From my earliest days, I discovered the wonders of wildlife, which inspired me to make biology my career. After completing my doctoral thesis, I was recruited by INRA as a research engineer to develop germline transgenesis in the silkworm Bombyx mori. My career continued at the CNRS, where I specialised on the functioning of the nerve/muscle pair. At the twilight of my career, I joined Ambra Mari’s team to study the behaviour of nucleoli in muscle fibre nuclei following the stress of experimental and pathophysiological denervation in a murine model of SMA.

Outside of work, as I enjoy physical activity, I have practised sports since I was very young, mainly judo and karate for a total of 28 years, but also horse riding, scuba diving, mountain biking and, today, shooting and climbing. Since the age of 18, I have been a motorcyclist and speed enthusiast, hence my love for sports bikes, but I also enjoy riding more leisurely motorcycles to take in the magnificent landscapes of our beautiful country. As a result, I love mechanics and technology, and as military aviation has always fascinated me, I take pleasure to design and build model aeroplanes and fly them using a jet engine. I really enjoy flying my jet planes and sharing the wonder of their flights with my friends.
What characterises me most, in my opinion, is curiosity, the need to understand and experiment, and above all, sharing experiences, knowledge, and know-how through exchanges.

Events

Team-Building on the Saône

Lise-Marie Donnio, Jean-Luc Thomas, Pierre-Olivier Mari +6 more

Stepping outside the lab to reconnect as a team. Today, we shared a canoe-kayak team building day on the Saône […]

Club Aquatique de Parcieux

The Mari team wishes you a Merry Christmas and a Happy New Year 2026

Lise-Marie Donnio, Pierre-Olivier Mari, Ambra Giglia-Mari +8 more

With enthusiasm and determination, we look forward to the year ahead, ready to embrace new challenges, advance our work, and […]

Publications

Couturier N, Castellano L, Ghasemizadeh A, Christin E, Sébastien M, Brun CE, Caillol D, Malleval C,..., NuMA1 controls myonuclear motility in striated skeletal muscle through AMPK activity and is impaired in Duchenne muscular dystrophy., Cell Death Dis 2026 Jun; (): .

Osseni A, Thomas JL, Ghasemizadeh A, Schaeffer L, Gache V, Simple Methods for Permanent or Transient Denervation in Mouse Sciatic Nerve Injury Models., Bio Protoc 2022 Jun; 12(11): .

Ghasemizadeh A, Christin E, Guiraud A, Couturier N, Abitbol M, Risson V, Girard E, Jagla C, Soler C,..., MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis., Elife 2021 Aug; 10(): .

Cao W, Aubert J, Maillard MB, Boissel F, Leduc A, Thomas JL, Deutsch SM, Camier B, Kerjouh A, Parayr..., Fine-Tuning of Process Parameters Modulates Specific Metabolic Bacterial Activities and Aroma Compound Production in Semi-Hard Cheese., J Agric Food Chem 2021 Aug; 69(30): 8511-8529.

Osseni A, Ravel-Chapuis A, Thomas JL, Gache V, Schaeffer L, Jasmin BJ, HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions., J Cell Biol 2020 Aug; 219(8): .

Robin JD, Jacome Burbano MS, Peng H, Croce O, Thomas JL, Laberthonniere C, Renault V, Lototska L, Po..., Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime., Aging Cell 2020 Mar; 19(3): e13097.

Thomas JL, Moncollin V, Ravel-Chapuis A, Valente C, Corda D, Méjat A, Schaeffer L, PAK1 and CtBP1 Regulate the Coupling of Neuronal Activity to Muscle Chromatin and Gene Expression., Mol Cell Biol 2015 Dec; 35(24): 4110-20.

Ratti F, Ramond F, Moncollin V, Simonet T, Milan G, Méjat A, Thomas JL, Streichenberger N, Gilquin ..., Histone deacetylase 6 is a FoxO transcription factor-dependent effector in skeletal muscle atrophy., J Biol Chem 2015 Feb; 290(7): 4215-24.

Becquemont L, Benattar-Zibi L, Bertin P, Berrut G, Corruble E, Danchin N, Delespierre T, Derumeaux G..., National observatory on the therapeutic management in ambulatory care patients aged 65 and over, with type 2 diabetes, chronic pain or atrial fibrillation., Therapie 2013 ; 68(4): 265-83.

Wetten AC, Thomas JL, Wagiran A, Chiurugwi T, Targeted biolistics for improved transformation of Impatiens balsamina., Methods Mol Biol 2012 ; 847(): 255-65.

Ravel-Chapuis A, Vandromme M, Thomas JL, Schaeffer L, Postsynaptic chromatin is under neural control at the neuromuscular junction., EMBO J 2007 Feb; 26(4): 1117-28.

Thomas JL, Electroporation, an alternative to biolistics for transfection of Bombyx mori embryos and larval tissues., J Insect Sci 2003 ; 3(): 17.