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Mechanisms controlling muscle maintenance and regeneration, and their role in the development of muscle diseases are not yet fully known. Metabolism is a key factor exerting a tight coordination between organelles, cell types, and tissues to support muscle homeostasis. Our team aims to identify the role of metabolic cross-talk in striated muscle maintenance in physiological and pathophysiological conditions with a multi-scale approach; encompassing 1) the cellular level, addressing the cross-talk between (metabolic) organelles within and between muscle cells; 2) the organ level, addressing the cross-talk between cells via alterations in local (metabolic) microenvironment; and 3) the organism level, addressing the cross-talk between different organ systems via alterations in the systemic (metabolic) environment.