About
Muscle atrophy is a debilitating and life-threatening syndrome associated with chronic diseases such as cancer, myopathy, chronic obstructive pulmonary and kidney failure as well as aging sarcopenia. Members of the Transforming Growth Factor β family, TGF-β, myostatin, activin, are central regulators of muscle mass. The diversity of ligands and receptors prevents a precise description of the consequences of chronic TGFβ activation by classical gain and loss of function approaches. We have developed a genetic model allowing inducible muscle specific activation of chronic TGF-β signaling. New molecular signatures of muscle atrophy emerging from our study will provide future therapeutic perspectives for muscle wasting prevention and treatment.