About
Mechanisms controlling muscle maintenance and regeneration, and their role in the development of muscle diseases are not yet fully known. Metabolism is a key factor exerting a tight coordination between organelles, cell types, and tissues to support muscle homeostasis. Our team aims to identify the role of metabolic cross-talk in striated muscle maintenance in physiological and pathophysiological conditions with a multi-scale approach; encompassing 1) the cellular level, addressing the cross-talk between (metabolic) organelles within and between muscle cells; 2) the organ level, addressing the cross-talk between cells via alterations in local (metabolic) microenvironment; and 3) the organism level, addressing the cross-talk between different organ systems via alterations in the systemic (metabolic) environment.
Members
Projects
We and others have previously demonstrated a change in metabolism during the muscle stem cell fate. This may serve to […]
The rejuvenation effect of senescent cell removal from aged skeletal muscle can be partially attributed to beneficial effects on the […]
Metastasis is the leading cause of death from cancer. Most cancers metastasize to organs such as the lung, liver or […]