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Our team aims to understand, in the model of skeletal muscle fibers, mechanisms controlling genome expression, cytoskeleton rearrangements and nuclear domain establishment and their implication in pathological contexts such as genetic disorders (Emery-Dreifuss Muscular Dystrophy and Centronuclear myopathies) or physiological aging (Sarcopenia). We also aim, in the model of cardiomyocyte, decipher implication of mutations identified in cardiomyopathies such as inherited hypertrophic cardiomyopathies (HCM), Atrial fibrillation (AF) or Arrhythmogenic right ventricular cardiomyopathy (ARVC).