Architecture du noyau et du cytosquelette musculaire – PGNM

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Nucleolar Dynamic Reorganization in action during DNA Repair (Nu-DyRection)

Energy metabolism and neuronal development

About

Our team aims to understand, in the model of skeletal muscle fibers, mechanisms controlling genome expression, cytoskeleton rearrangements and nuclear domain establishment and their implication in pathological contexts such as genetic disorders (Emery-Dreifuss Muscular Dystrophy and Centronuclear myopathies) or physiological aging (Sarcopenia). We also aim, in the model of cardiomyocyte, decipher implication of mutations identified in cardiomyopathies such as inherited hypertrophic cardiomyopathies (HCM), Atrial fibrillation (AF) or Arrhythmogenic right ventricular cardiomyopathy (ARVC).

Members

Gaelle Boncompain

Vanessa del Vito

Tanushri Dargar

Anna Raush de Traubenberg

Emilie Christin

Ludivine Rotard

Pauline Goddard

Philippe Chevalier

Alexandre Janin

Catarina Placido da Rocha

Justin Rouviere

Carole Kretz-Remy

PU Ex, UCBL1, HDR

Projects

Evolution of the microtubule proteome and its involvement in the formation and maintenance of nuclear domains (MNDs) during skeletal muscle development

The nuclei actively position themselves throughout muscle development. Extensive data support a direct connection between the regulation of nuclear domains, […]

Deciphering the signaling pathways regulated by the primary cilium in muscle stem cells

The function of skeletal muscle tissue relies on the maintenance and regeneration of myofibers through a finely regulated process. It […]

Modulation of skeletal muscle integrity in healthy and pathological contexts

The functioning of the muscle fiber (myofiber) is supported by precise positioning of its organelles and nuclei. The contractile force […]

Carole Kretz-Remy

Mechanisms of membrane trafficking in differentiated cells

Secretory protein transport is necessary to fulfil essential cellular functions, enabling communication between cells, tissue maintenance and specialized functions. Differentiated […]

Gaelle Boncompain

Mutations identification and implication in the physiopathology of cardiomyopathies

Cardiac arrhythmias are cardiomyopathies that regroup different pathophysiological syndromes such as atrial fibrillation, tachycardia and ventricular fibrillation. Deciphering molecular mechanisms […]

Philippe Chevalier

Publications

Rhyma Hakkar, Caroline E Brun, Pascal Leblanc, Emmanuelle Meugnier, Emmanuelle Berger‐danty, Olivi..., Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration, Journal of extracellular vesicles.

Marion Bouvet, Vincent Gache, J. Sohier, Development of injectable and porous hydrogels containing Bioactive Glass (BG) for skeletal muscle tissue engineering, .

Guiraud A, Couturier N, Christin E, Castellano L, Daura M, Kretz-Remy C, Janin A, Ghasemizadeh A, De..., SH3KBP1 promotes skeletal myofiber formation and functionality through ER/SR architecture integrity., EMBO Rep 2025 Apr; 26(8): 2166-2191.

Alireza Ghasemizadeh, Vincent Gache, [Myonuclear domain settings by microtubules and MACF1]. Contrôles des paramètres des domaines nucléaires par les microtubules et la protéine MACF1, Médecine/Sciences.

Louise Griveau, Marion Bouvet, Emilie Christin, Cloé Paret, Lauriane Lecoq, Sylvie Radix, Thomas La..., Synthetic injectable and porous hydrogels for the formation of skeletal muscle fibers: Novel perspectives for the acellular repair of substantial volumetric muscle loss, Journal of Tissue Engineering and Regenerative Medicine.

Marion Bouvet, Cloé Paret, Vincent Gache, J. Sohier, Synthetic injectable and porous hydrogels: novel perspectives for the acellular repair of severe muscle loss, .

Marie Abitbol, Caroline Dufaure de Citres, Gabriela Rudd Garces, Gesine Lühken, Leslie Lyons, Vince..., Different Founding Effects Underlie Dominant Blue Eyes (DBE) in the Domestic Cat, Animals.

Marie Abitbol, Alice Couronné, Caroline Dufaure de Citres, Vincent Gache, Caroline Dufaure de Citre..., A PAX3 insertion in the Celestial breed and certain feline breeding lines with dominant blue eyes, Animal Genetics.

Léa Castellano, Vincent Gache, [Microtubular network and functionality of the striated skeletal muscle]. Réseau microtubulaire et fonctionnalité du muscle strié squelettique, Médecine/Sciences.

Cloé Paret, Vincent Gache, J. Sohier, Injectable and porous hydrogel fate as scaffold in Volumetric Muscle Loss context, .

Alexis Osseni, Jean-Luc Thomas, Alireza Ghasemizadeh, Laurent Schaeffer, Jean- Thomas, Vincent Gache, Simple Methods for Permanent or Transient Denervation in Mouse Sciatic Nerve Injury Models, Bio Protoc 2022 Jun; 12(11): .

Alexis Osseni, Aymeric Ravel-Chapuis, Jean-Luc Thomas, Vincent Gache, Laurent Schaeffer, Bernard Jas..., HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions, J Cell Biol 2020 Aug; 219(8): .

Alexandre Guiraud, Emilie Christin, Nathalie Couturier, Carole Kretz-Remy, Alexandre Janin, Alireza ..., SH3KBP1 scaffolds endoplasmic reticulum and controls skeletal myofibers architecture and integrity, .

Alireza Ghasemizadeh, Emilie Christin, Alexandre Guiraud, Nathalie Couturier, Valérie Risson, Emman..., Skeletal muscle MACF1 maintains myonuclei and mitochondria localization through microtubules to control muscle functionalities, .

Rosa Doñate Puertas, Gilles Millat, Isabelle Ernens, Vincent Gache, Samuel Chauveau, Elodie Morel, ..., Atrial Structural Remodeling Gene Variants in Patients with Atrial Fibrillation, BioMed Research International.

Alexandre Janin, Vincent Gache, Nesprins and Lamins in Health and Diseases of Cardiac and Skeletal Muscles, Frontiers in Physiology.

Nathalie Couturier, Vincent Gache, Prix Master 2016 de la SFM, Médecine/Sciences.

Vincent Gache, E. Gomes, B. Cadot, Microtubule motors involved in nuclear movement during skeletal muscle differentiation, Molecular Biology of the Cell.