Project: Mutations identification and implication in the physiopathology of cardiomyopathies

About

Cardiac arrhythmias are cardiomyopathies that regroup different pathophysiological syndromes such as atrial fibrillation, tachycardia and ventricular fibrillation. Deciphering molecular mechanisms implicated in these cardiomyopathies will help the identification of therapeutics targets and the development of new treatments. We are leading a systematic approach that consists in the identification of mutations in patients with related cardiomyopathies. Using iPSCs (Induced pluripotent stem cells) and CRISPR/Cas9 technology, we are developing cardiomyocytes with identified mutations and decipher in vitro implication of associated genome alterations on the behavior of those cells.