Towards a better understanding of the pathophysiology of Friedreich Ataxia (FA) and Cerebellar ataxia with CoQ10 deficiency (ARCA2).

Theme

Identification and validation of biomarkers for FA and ARCA2

Resistance of skeletal muscle to the metastatic process

About

Our goals are to better define the function of the disease proteins and to decipher the cellular and molecular pathways involved in the diseases. We are studying faithful mouse, zebrafish and cell model of the diseases, using a wide range of techniques from biochemistry and Omics (transcriptomic, epigenomic, proteomic, metabolomics) to functional and behavioural analyses.