Project: Muscle stem cell neighboring

About

Skeletal muscle regeneration is associated with the presence of macrophages. Two main inflammatory types of macrophages are present during skeletal muscle regeneration. Soon after injury, inflammatory monocytes enter into the damaged muscle and these inflammatory macrophages stimulate the proliferation of muscle stem cells. Later, they switch their phenotype into anti-inflammatory macrophages that sustain myogenic differentiation and myofiber growth.

Macrophages can be considered as a stromal support for myogenic cells that helps the sequential steps of skeletal muscle regeneration. Our research focuses on the molecular mechanisms that regulate the inflammatory status and functions of macrophages during this process.

We also study macrophage functions during myopathies, where they are associated with fibrosis.

We also investigate the interactions between muscle stem cells and vessel cells, since satellite cells are located close to capillaries in normal muscle. Endothelial cells and myoge