Mitochondrial Quality Control in Muscle Stem Cells: A Determinant of Fate Decision and Tissue Repair Capacity

Description

Abstract Maintenance of optimal mitochondrial function plays a crucial role in the regulation of muscle stem cell (MuSC) behavior, but the underlying maintenance mechanisms remain ill defined. Our lab aims to delineate the importance of mitophagy as a mitochondrial quality control regulator in MuSCs and the role this process plays in maintaining optimal muscle regenerative capacity. In this seminar I will summarize results from our recent unpublished work in which we characterized the dynamics and regulation of mitophagy in MuSCs under various physiological myogenic states and identified an important role for both Ubiquitin- and Receptor-dependent mitophagy in the regulation of MuSC fate decision and muscle regeneration.

Cairns G, Thumiah-Mootoo M, Abassi MR, Racine J, Larionov N , Prola A, Khacho M , Burelle Y PINK1 Deficiency Alters Muscle Stem Cell Fate Decision and Muscle Regenerative Capacity. BioRxiv 2023.06.23.546123; doi: https://doi.org/10.1101/2023.06.23.546123

Baker N, Wade S, Triolo M, Girgis J, Chwastek D, Larrigan S, Feige P, Fujita R, Crist C, Rudnicki MA, Burelle Y, Khacho M.The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells. Cell Stem Cell. 2022 Sep 1;29(9):1315- 1332.e9.

Cairns G, Thumiah-Mootoo M, Burelle Y, Khacho Mitophagy: A New Player in Stem Cell Biology. M.Biology (Basel). 2020 Dec 19;9(12):481. doi: 10.3390/biology9120481.