About
Muscle fibers are multinucleated, post-mitotic and long-lived cells, whose homeostasis is crucial for muscle function. While epigenetic changes and genomic stability have been demonstrated to be crucial for the maintenance of muscle fiber homeostasis, how these events are established and coordinated is poorly investigated. Several evidence indicates that histone variants, replacing conventional histones during postnatal life, play a key role in muscle plasticity. Thus, the project aims at dissecting the function of the histone variants in post-mitotic muscle fibers by using muscle-specific knock-out models.